Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair

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Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair.

The peripheral nervous system has a limited innate capacity for self-repair following injury, and surgical intervention is often required. For injuries greater than a few millimeters autografting is standard practice although it is associated with donor site morbidity and is limited in its availability. Because of this, nerve guidance conduits (NGCs) can be viewed as an advantageous alternative...

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Collagen-chitosan nerve guides for peripheral nerve repair: a histomorphometric study.

Currently a wide variety of polymer materials are being applied to fabricate nerve guide tubes to repair injured peripheral nerves. In this study we have examined whether collagen-chitosan nerve guides promotes nerve repair compared to chitosan nerve guides using histological analysis. Results indicates that the enclosed structure of the nerve guide both promotes and supports axonal sprouting. ...

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Peripheral nerve injury and repair.

Peripheral nerve injuries are common, and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories: neurapraxia, axonotmesis, and neurotmesis. After complete axonal transection, the neuron undergoes a number of degenerative processes, followed by attempts at regeneration. A distal growth cone see...

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Nanotechnology for peripheral nerve regeneration

Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...

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Nanotechnology for peripheral nerve regeneration

Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...

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ژورنال

عنوان ژورنال: Biomaterials

سال: 2015

ISSN: 0142-9612

DOI: 10.1016/j.biomaterials.2015.01.055